作者
Carol L Shields, Fairooz P Manjandavida, Sruthi Arepalli, Swathi Kaliki, Sara E Lally, Jerry A Shields
发表日期
2014/3/1
期刊
JAMA ophthalmology
卷号
132
期号
3
页码范围
319-325
出版商
American Medical Association
简介
Importance
Recurrent or persistent vitreous seeds following treatment of retinoblastoma poses difficult management and often leads to enucleation.
Objective
To describe the technique and evaluate the efficacy and complications of intravitreal melphalan for vitreous seeding from retinoblastoma.
Design, Setting, and Participants
This retrospective noncomparative analysis was conducted at a tertiary referral center. The study included 11 consecutive eyes of 11 patients with viable persistent or recurrent vitreous seeds following treatment of retinoblastoma.
Interventions
All eyes received intravitreal melphalan injection (20-30 µg) by transconjunctival pars plana route with concomitant triple-freeze cryotherapy at the injection site during needle withdrawal for prevention of extraocular seeding. Each patient was offered planned 6 monthly cycles.
Main Outcomes and Measures
Vitreous seed control and complications of …
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CL Shields, FP Manjandavida, S Arepalli, S Kaliki… - JAMA ophthalmology, 2014