作者
Shouyi Wei, Haibo Lin, Chengyu Shi, Weijun Xiong, Chin‐Cheng Chen, Sheng Huang, Robert H Press, Shaakir Hasan, Arpit M Chhabra, J Isabelle Choi, Charles B Simone, Minglei Kang
发表日期
2022/10
期刊
Medical physics
卷号
49
期号
10
页码范围
6560-6574
简介
Purpose
The transmission proton FLASH technique delivers high doses to the normal tissue distal to the target, which is less conformal compared to the Bragg peak technique. To investigate FLASH radiotherapy (RT) planning using single‐energy Bragg peak beams with a similar beam arrangement as clinical intensity‐modulated proton therapy (IMPT) in a liver stereotactic body radiation therapy (SBRT) and to characterize the plan quality, dose sparing of organs‐at‐risk (OARs), and FLASH dose rate percentage.
Materials and methods
An in‐house platform was developed to enable inverse IMPT‐FLASH planning using single‐energy Bragg peaks. A universal range shifter and range compensators were utilized to effectively align the Bragg peak to the distal edge of the target. Two different minimum MU settings of 400 and 800 MU/spot (Bragg‐400 MU and Bragg‐800 MU) plans were investigated on 10 …
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S Wei, H Lin, C Shi, W Xiong, CC Chen, S Huang… - Medical physics, 2022