作者
Thomas van Doeveren, Jose A Nakauma‐Gonzalez, Andrew S Mason, Geert JLH van Leenders, Tahlita CM Zuiverloon, Ellen C Zwarthoff, Isabelle C Meijssen, Angelique C van der Made, Antoine G van Der Heijden, Kees Hendricksen, Bas WG van Rhijn, Charlotte S Voskuilen, Job van Riet, Winand NM Dinjens, Hendrikus J Dubbink, Harmen JG van de Werken, Joost L Boormans
发表日期
2021/2/15
期刊
International Journal of Cancer
卷号
148
期号
4
页码范围
981-987
出版商
John Wiley & Sons, Inc.
简介
The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2 years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate origins. To investigate the clonal relationship between both entities, we performed targeted DNA sequencing of a panel of 41 genes on matched normal and tumor tissue of 15 primary UTUC patients treated by RNU who later developed 19 UCBs. Based on the detected tumor‐specific DNA aberrations, the paired UTUC and UCB(s) of 11 patients (73.3%) showed a clonal relation, whereas in four patients the molecular results did not indicate a clear clonal relationship. Our results support the hypothesis that UCBs following a primary surgically resected UTUC are predominantly clonally …
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T van Doeveren, JA Nakauma‐Gonzalez, AS Mason… - International Journal of Cancer, 2021