作者
Timothy F Gallagher, George L Seibel, Shouki Kassis, Jeffrey T Laydon, Mary Jane Blumenthal, John C Lee, Dennis Lee, Jeffrey C Boehm, Susan M Fier-Thompson, Jeffrey W Abt, Margaret E Soreson, Juanita M Smietana, Ralph F Hall, Ravi S Garigipati, Paul E Bender, Karl F Erhard, Arnold J Krog, Glenn A Hofmann, Peter L Sheldrake, Peter C McDonnell, Sanjay Kumar, Peter R Young, Jerry L Adams
发表日期
1997/1/1
期刊
Bioorganic & Medicinal Chemistry
卷号
5
期号
1
页码范围
49-64
出版商
Pergamon
简介
Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential modes of binding to the enzyme are presented. For a subset of pyridinylimidazoles, binding is shown to correlate with inhibition of CSBP kinase activity, whereas no significant inhibition of PKA, PKCα and ERK kinase activity is observed.
引用总数
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TF Gallagher, GL Seibel, S Kassis, JT Laydon… - Bioorganic & Medicinal Chemistry, 1997