作者
David A Gutman, Lee AD Cooper, Scott N Hwang, Chad A Holder, JingJing Gao, Tarun D Aurora, William D Dunn Jr, Lisa Scarpace, Tom Mikkelsen, Rajan Jain, Max Wintermark, Manal Jilwan, Prashant Raghavan, Erich Huang, Robert J Clifford, Pattanasak Mongkolwat, Vladimir Kleper, John Freymann, Justin Kirby, Pascal O Zinn, Carlos S Moreno, Carl Jaffe, Rivka Colen, Daniel L Rubin, Joel Saltz, Adam Flanders, Daniel J Brat
发表日期
2013/5
期刊
Radiology
卷号
267
期号
2
页码范围
560-569
出版商
Radiological Society of North America, Inc.
简介
Purpose
To conduct a comprehensive analysis of radiologist-made assessments of glioblastoma (GBM) tumor size and composition by using a community-developed controlled terminology of magnetic resonance (MR) imaging visual features as they relate to genetic alterations, gene expression class, and patient survival.
Materials and Methods
Because all study patients had been previously deidentified by the Cancer Genome Atlas (TCGA), a publicly available data set that contains no linkage to patient identifiers and that is HIPAA compliant, no institutional review board approval was required. Presurgical MR images of 75 patients with GBM with genetic data in the TCGA portal were rated by three neuroradiologists for size, location, and tumor morphology by using a standardized feature set. Interrater agreements were analyzed by using the Krippendorff α statistic and intraclass correlation coefficient. Associations …
学术搜索中的文章
DA Gutman, LAD Cooper, SN Hwang, CA Holder… - Radiology, 2013