作者
Andrew J Swift, Dave Capener, Chris Johns, Neil Hamilton, Alex Rothman, Charlie Elliot, Robin Condliffe, Athanasios Charalampopoulos, Smitha Rajaram, Allan Lawrie, Michael J Campbell, Jim M Wild, David G Kiely
发表日期
2017/7/15
期刊
American journal of respiratory and critical care medicine
卷号
196
期号
2
页码范围
228-239
出版商
American Thoracic Society
简介
Rationale: Prognostication is important when counseling patients and defining treatment strategies in pulmonary arterial hypertension (PAH).
Objectives: To determine the value of magnetic resonance imaging (MRI) metrics for prediction of mortality in PAH.
Methods: Consecutive patients with PAH undergoing MRI were identified from the ASPIRE (Assessing the Spectrum of Pulmonary Hypertension Identified at a Referral Centre) pulmonary hypertension registry.
Measurements and Main Results: During the follow-up period of 42 (range, 17–142) months 576 patients were studied and 221 (38%) died. A derivation cohort (n = 288; 115 deaths) and validation cohort (n = 288; 106 deaths) were identified. We used multivariate Cox regression and found two independent MRI predictors of death (P < 0.01): right ventricular end-systolic volume index adjusted for age and sex, and the relative area change of the …
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AJ Swift, D Capener, C Johns, N Hamilton, A Rothman… - American journal of respiratory and critical care …, 2017