作者
Kristine H Allin, Valentina Tremaroli, Robert Caesar, Benjamin AH Jensen, Mads TF Damgaard, Martin I Bahl, Tine R Licht, Tue H Hansen, Trine Nielsen, Thomas M Dantoft, Allan Linneberg, Torben Jørgensen, Henrik Vestergaard, Karsten Kristiansen, Paul W Franks, IMI-DIRECT consortium, Torben Hansen, Fredrik Bäckhed, Oluf Pedersen
发表日期
2018/4
期刊
Diabetologia
卷号
61
页码范围
810-820
出版商
Springer Berlin Heidelberg
简介
Aims/hypothesis
Individuals with type 2 diabetes have aberrant intestinal microbiota. However, recent studies suggest that metformin alters the composition and functional potential of gut microbiota, thereby interfering with the diabetes-related microbial signatures. We tested whether specific gut microbiota profiles are associated with prediabetes (defined as fasting plasma glucose of 6.1–7.0 mmol/l or HbA1c of 42–48 mmol/mol [6.0–6.5%]) and a range of clinical biomarkers of poor metabolic health.
Methods
In the present case–control study, we analysed the gut microbiota of 134 Danish adults with prediabetes, overweight, insulin resistance, dyslipidaemia and low-grade inflammation and 134 age- and sex-matched individuals with normal glucose regulation.
Results
We found that five bacterial genera and 36 …
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KH Allin, V Tremaroli, R Caesar, BAH Jensen… - Diabetologia, 2018