作者
Samuel Sarrazin, Arnaud Cachia, Franz Hozer, Colm McDonald, Louise Emsell, Dara M Cannon, Michele Wessa, Julia Linke, Amelia Versace, Nora Hamdani, Marc‐Antoine D'Albis, Marine Delavest, Mary L Phillips, Paolo Brambilla, Marcella Bellani, Mircea Polosan, Pauline Favre, Marion Leboyer, Jean‐François Mangin, Josselin Houenou
发表日期
2018/12
期刊
Bipolar disorders
卷号
20
期号
8
页码范围
721-732
简介
Objectives
Brain sulcation is an indirect marker of neurodevelopmental processes. Studies of the cortical sulcation in bipolar disorder have yielded mixed results, probably due to high variability in clinical phenotype. We investigated whole‐brain cortical sulcation in a large sample of selected patients with high neurodevelopmental load.
Methods
A total of 263 patients with bipolar disorder I and 320 controls were included in a multicentric magnetic resonance imaging (MRI) study. All subjects underwent high‐resolution T1‐weighted brain MRI. Images were processed with an automatized pipeline to extract the global sulcal index (g‐SI) and the local sulcal indices (l‐SIs) from 12 a priori determined brain regions covering the whole brain. We compared l‐SI and g‐SI between patients with and without early‐onset bipolar disorder and between patients with and without a positive history of psychosis, adjusting for age …
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S Sarrazin, A Cachia, F Hozer, C McDonald, L Emsell… - Bipolar disorders, 2018