作者
Albert Akpalu, Fred Stephen Sarfo, Bruce Ovbiagele, Rufus Akinyemi, Mulugeta Gebregziabher, Reginald Obiako, Lukman Owolabi, Kwamena Sagoe, Carolyn Jenkins, Oyedunni Arulogun, Sheila Adamu, Lambert T Appiah, Martin A Adadey, Francis Agyekum, Joseph A Quansah, Yaw B Mensah, Abiodun M Adeoye, Arti Singh, Aridegbe O Tosin, Osimhiarherhuo Ohifemen, Abubabkar A Sani, Eric Tabi-Ajayi, Ibinaiye O Phillip, Suleiman Y Isah, Nasir A Tabari, Aliyu Mande, Atinuke M Agunloye, Godwin I Ogbole, Joshua O Akinyemi, Onoja M Akpa, Ruth Laryea, Sylvia Ezinne Melikam, Dorcas Adinku, Ezinne Uvere, Nina-Serena Burkett, Gregory F Adekunle, Salaam I Kehinde, Paschal C Azuh, Abdul H Dambatta, Naser A Ishaq, Donna Arnett, Hemant K Tiwari, Dan Lackland, Mayowa Owolabi, SIREN as part of the H3Africa Consortium
发表日期
2015/8/19
来源
Neuroepidemiology
卷号
45
期号
2
页码范围
73-82
出版商
S. Karger AG
简介
Background: As the second leading cause of death and the leading cause of adult-onset disability, stroke is a major public health concern particularly pertinent in Sub-Saharan Africa (SSA), where nearly 80% of all global stroke mortalities occur, and stroke burden is projected to increase in the coming decades. However, traditional and emerging risk factors for stroke in SSA have not been well characterized, thus limiting efforts at curbing its devastating toll. The Stroke Investigative Research and Education Network (SIREN) project is aimed at comprehensively evaluating the key environmental and genomic risk factors for stroke (and its subtypes) in SSA while simultaneously building capacities in phenomics, biobanking, genomics, biostatistics, and bioinformatics for brain research. Methods: SIREN is a transnational, multicentre, hospital and community-based study involving 3,000 cases and …
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