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Sir, Sclerosing epithelioid fibrosarcoma (SEF) and low grade fibromyxoid sarcoma (LGFMS) are malignant fibroblastic neoplasms that are believed to be related and belong to the same lesional spectrum. 1 e3 Some cases morphologically show features of both SEF and LGFMS and they are known as hybrid SEF/LGFMS. 2 e5 There are similarities between both entities at morphological, immunohistochemical and molecular levels. 1, 3 LGFMS is relatively more common than SEF and has a less aggressive clinical course in the first 5 years following excision in terms of local recurrence and distant metastasis. 1, 2, 4 The majority of LGFMS cases exhibit t (7; 16) chromosomal translocation resulting in FUSCREB3L2 gene fusion, and a lower percentage of cases can display t (11; 16) with FUS-CREB3L1 fusion. 1 e4 However, EWSR1-CREB3L1 gene fusion has shown to be a recurrent alteration in SEF. 2 e4 Herein, we …