作者
Terry Purton, Lada Staskova, Melissa M Lane, Samantha L Dawson, Madeline West, Joseph Firth, Gerard Clarke, John F Cryan, Michael Berk, Adrienne O’Neil, Olivia Dean, Amir Hadi, Cynthia Honan, Wolfgang Marx
发表日期
2021/4/1
来源
Neuroscience & Biobehavioral Reviews
卷号
123
页码范围
1-13
出版商
Pergamon
简介
This systematic review aimed to synthesise the results from studies investigating the effects of prebiotics and probiotics on kynurenine pathway metabolism. Thirteen studies were identified for inclusion, comprising 12 probiotic and two prebiotic arms. Participants included healthy individuals and individuals with various clinical conditions. Twelve metabolites were examined across the studies, using a range of biological samples. Across all interventions, 11 reported an effect on ≤ metabolite. Although limited by clinical and methodological heterogeneity, pooled analysis (n = 253) found probiotics to significantly affect serum kynurenine (g = 0.315, CI = 0.070 to 0.560, p = 0.012, 4 studies, I2 = 0%) and the kynurenine:tryptophan ratio (g = 0.442, CI = 0.074 to 0.810, p = 0.018, 4 studies, I2 = 42 %). Risk of bias across the studies was generally low. The results provide preliminary evidence that …
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T Purton, L Staskova, MM Lane, SL Dawson, M West… - Neuroscience & Biobehavioral Reviews, 2021