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Metal nanoparticles have been of interest to the field of nanomedicine due to their potential for cancer treatment, diagnosis, and antimicrobial activity. Particularly, platinum nanoparticles (PtNPs) have been reported to have remarkable anticancer effects and low toxicity in healthy cells. In this paper, we propose a delivery system for PtNPs as a substitute for common chemotherapy treatment. The anticancer effect of PtNPs was tested against triple negative breast cancer (TNBC) showing no cell viability for most of the concentrations used, while not being toxic against fibroblasts. To improve accumulation at the tumor site, a delivery system based on poly(lactic-co-glycolic acid) (PLGA) particles was used. Encapsulation was achieved by nanoemulsion, resulting in 59% PLGA particles containing PtNPs, and 12.5% PtNPs by weight. To improve the circulation time and specificity of the system, the PLGA particle surface …