作者
Karl W Huesgen, Yasmeen O Elmelige, Zhihui Yang, Muhammad Abdul Baker Chowdhury, Sarah Gul, Carolina B Maciel, Marie-Carmelle Elie-Turenne, Torben K Becker, Scott A Cohen, Amy Holland, Cindy Montero, Tian Zhu, Kevin K Wang, Joseph A Tyndall
发表日期
2021/9/1
期刊
Resuscitation Plus
卷号
7
页码范围
100133
出版商
Elsevier
简介
Objectives
To assess ultra-early neuroprognostic significance of GFAP, NF-L, UCH-L1, tau, and S100B concentrations, change trajectory, and combination profile after Out-of-Hospital Cardiac Arrest (OHCA).
Methods
Prospective enrollment of 22 OHCA and 10 control patients at an academic tertiary care center between May 1, 2017 and January 28, 2020. Blood was collected within one hour of return of spontaneous circulation (ROSC) (H0), at hours 6 (H6), 12, 18, 24, and daily or until discharge or death. Biomarker concentrations, multifactor score, and trajectory change were assessed and compared to final neurologic status (good vs poor Cerebral Performance Category; CPC 1–2 vs CPC 3–5, respectively).
Results
10 patients had good and 12 had poor neurologic outcomes. Poor outcome patients had higher biomarker concentrations and combined biomarker scores at early time points. The earliest significant …
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KW Huesgen, YO Elmelige, Z Yang, MAB Chowdhury… - Resuscitation Plus, 2021