作者
Peter Ganz, Bettina Heidecker, Kristian Hveem, Christian Jonasson, Shintaro Kato, Mark R Segal, David G Sterling, Stephen A Williams
发表日期
2016/6/21
期刊
Jama
卷号
315
期号
23
页码范围
2532-2541
出版商
American Medical Association
简介
Importance
Precise stratification of cardiovascular risk in patients with coronary heart disease (CHD) is needed to inform treatment decisions.
Objective
To derive and validate a score to predict risk of cardiovascular outcomes among patients with CHD, using large-scale analysis of circulating proteins.
Design, Setting, and Participants
Prospective cohort study of participants with stable CHD. For the derivation cohort (Heart and Soul study), outpatients from San Francisco were enrolled from 2000 through 2002 and followed up through November 2011 (≤11.1 years). For the validation cohort (HUNT3, a Norwegian population-based study), participants were enrolled from 2006 through 2008 and followed up through April 2012 (5.6 years).
Exposures
Using modified aptamers, 1130 proteins were measured in plasma samples.
Main Outcomes and Measures
A 9-protein risk score was derived and validated for 4-year …
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P Ganz, B Heidecker, K Hveem, C Jonasson, S Kato… - Jama, 2016