作者
Deepak K Semwal, Randhir S Dahiya, Naveen Joshi, Ruchi B Semwal, Sonali Aswal, Ankit Kumar, Ashutosh Chauhan, Abhimanyu Kumar
发表日期
2018/12/1
期刊
Current Traditional Medicine
卷号
4
期号
4
页码范围
297-304
出版商
Bentham Science Publishers
简介
Background and Objectives
Carica papaya leaves have been used in traditional medicine in Asian countries mainly in treating dengue. Various earlier studies proved their role in increasing platelet count in dengue patients. A precise mechanism of their action remains unknown. The present study aimed to evaluate the effect of C. papaya leaf extract on platelets and unravelling its possible mode of action.
Materials and Methods
The methanol (MEA) and acetone (ACA) extracts were studied for antiplatelet activity and bleeding time in rats whereas the decoction of leaves powder was clinically used in patients with low platelet count.
Results
The results showed that MEA, ACA and positive control (heparin) attenuated the platelets aggregation by 68%, 56% and 72%, respectively. On the other hand, MEA and ACA at 400 mg/kg significantly increased bleeding time in rats by 3 and 4 seconds, respectively, while the …
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DK Semwal, RS Dahiya, N Joshi, RB Semwal, S Aswal… - Current Traditional Medicine, 2018