作者
Reisa A Sperling, Elizabeth C Mormino, Aaron P Schultz, Rebecca A Betensky, Kathryn V Papp, Rebecca E Amariglio, Bernard J Hanseeuw, Rachel Buckley, Jasmeer Chhatwal, Trey Hedden, Gad A Marshall, Yakeel T Quiroz, Nancy J Donovan, Jonathan Jackson, Jennifer R Gatchel, Jennifer S Rabin, Heidi Jacobs, Hyun‐Sik Yang, Michael Properzi, Dylan R Kirn, Dorene M Rentz, Keith A Johnson
发表日期
2019/2
期刊
Annals of neurology
卷号
85
期号
2
页码范围
181-193
出版商
John Wiley & Sons, Inc.
简介
Objectives
Amyloid‐beta (Aβ) and tau pathologies are commonly observed among clinically normal older individuals at postmortem and can now be detected with in vivo neuroimaging. The association and interaction of these proteinopathies with prospective cognitive decline in normal aging and preclinical Alzheimer's disease (AD) remains to be fully elucidated.
Methods
One hundred thirty‐seven older individuals (age = 76.3 ± 6.22 years) participating in the Harvard Aging Brain Study underwent Aβ (11C‐Pittsburgh compound B) and tau (18F‐flortaucipir) positron emission tomography (PET) with prospective neuropsychological assessments following PET imaging (mean number of cognitive visits = 2.8 ± 1.1). Tau and Aβ PET measures were assessed in regions of interest (ROIs) as well as vertex‐wise map analyses. Cognitive change was evaluated with Memory and Executive Function composites.
Results …
学术搜索中的文章
RA Sperling, EC Mormino, AP Schultz, RA Betensky… - Annals of neurology, 2019
