作者
Alejandro Costoya-Sánchez, Alexis Moscoso, Jesús Silva-Rodríguez, Michael J Pontecorvo, Michael D Devous, Pablo Aguiar, Michael Schöll, Michel J Grothe, Michael W Weiner, Paul Aisen, Ronald Petersen, Clifford R Jack, William Jagust, John Q Trojanowki, Arthur W Toga, Laurel Beckett, Robert C Green, Andrew J Saykin, John C Morris, Richard J Perrin, Leslie M Shaw, Zaven Khachaturian, Maria Carrillo, William Potter, Lisa Barnes, Marie Bernard, Hector Gonzalez, Carole Ho, John K Hsiao, Jonathan Jackson, Eliezer Masliah, Donna Masterman, Ozioma Okonkwo, Laurie Ryan, Nina Silverberg, Adam Fleisher, Diana T Sacrey, Juliet Fockler, Cat Conti, Dallas Veitch, John Neuhaus, Chengshi Jin, Rachel Nosheny, Mariam Ashford, Derek Flenniken, Adrienne Kormos, Tom Montine, Michael Rafii, Rema Raman, Gustavo Jimenez, Michael Donohue, Devon Gessert, Jennifer Salazar, Caileigh Zimmerman, Yuliana Cabrera, Sarah Walter, Garrett Miller, Godfrey Coker, Taylor Clanton, Lindsey Hergesheimer, Stephanie Smith, Olusegun Adegoke, Payam Mahboubi, Shelley Moore, Jeremy Pizzola, Elizabeth Shaffer, Danielle Harvey, Arvin Forghanian-Arani, Bret Borowski, Chad Ward, Christopher Schwarz, David Jones, Jeff Gunter, Kejal Kantarci, Matthew Senjem, Prashanthi Vemuri, Robert Reid, Nick C Fox, Ian Malone, Paul Thompson, Sophia I Thomopoulos, Talia M Nir, Neda Jahanshad, Charles DeCarli, Alexander Knaack, Evan Fletcher, Duygu Tosun-Turgut, Stephanie R Chen, Mark Choe, Karen Crawford, Paul A Yuschkevich, Sandhitsu Das, Robert A Koeppe, Eric M Reiman, Kewei Chen, Chet Mathis, Susan Landau, Nigel J Cairns, Erin Householder, Erin Franklin, Haley Bernhardt, Lisa Taylor-Reinwald, Magdalena Korecka, Michal Figurski, Scott Neu, Kwangsik Nho, Shannon L Risacher, Liana G Apostolova, Li Shen, Tatiana M Foroud, Kelly Nudelman, Kelley Faber, Kristi Wilmes, Leon Thal, Keith A Johnson, Reisa A Sperling, Dorene Rentz, Rebecca E Amariglio, Deborah Blacker, Rachel Buckley, Jasmeer P Chhatwal, Brad Dickerson, Nancy Donovan, Michelle Farrell, Geoffroy Gagliardi, Jennifer Gatchel, Edmarie Guzman-Velez, Heidi Jacobs, Roos Jutten, Cristina Lois Gomez, Gad Marshall, Kate Oaoo, Enmanuelle Pardilla-Delgado, Juliet Price, Prokopis Prokopiou, Yakeel Quiroz, Gretchen Reynolds, Aaron Schultz, Stephanie Schultz, Jorge Sepulcre, Irina Skylar-Scott, Patrizia Vannini, Clara Vila-Castelar, Hyun-Sik Yang, Alzheimer’s Disease Neuroimaging Initiative
发表日期
2023/10/1
期刊
JAMA neurology
卷号
80
期号
10
页码范围
1051-1061
出版商
American Medical Association
简介
Importance
An increased tau positron emission tomography (PET) signal in the medial temporal lobe (MTL) has been observed in older individuals in the absence of amyloid-β (Aβ) pathology. Little is known about the longitudinal course of this condition, and its association with Alzheimer disease (AD) remains unclear.
Objective
To study the pathologic and clinical course of older individuals with PET-evidenced MTL tau deposition (TMTL+) in the absence of Aβ pathology (A−), and the association of this condition with the AD continuum.
Design, Setting, and Participants
A multicentric, observational, longitudinal cohort study was conducted using pooled data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), Harvard Aging Brain Study (HABS), and the AVID-A05 study, collected between July 2, 2015, and August 23, 2021. Participants in the ADNI, HABS, and AVID-A05 studies (N = 1093) with varying …
学术搜索中的文章
A Costoya-Sánchez, A Moscoso, J Silva-Rodríguez… - JAMA neurology, 2023