作者
Jennifer S Rabin, Jeremy Pruzin, Matthew Scott, Hyun-Sik Yang, Olivia Hampton, Stephanie Hsieh, Aaron P Schultz, Rachel F Buckley, Trey Hedden, Dorene Rentz, Keith A Johnson, Reisa A Sperling, Jasmeer P Chhatwal
发表日期
2022/7/19
期刊
Neurology
卷号
99
期号
3
页码范围
e270-e280
出版商
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
简介
Background and objectives
Vascular risk factors and elevated β-amyloid (Aβ) are commonly observed together among older adults. Here, we examined the interactive vs independent effects of systemic vascular risk and Aβ burden on longitudinal gray matter atrophy and how their co-occurrence may be related to cognitive decline in a cohort of clinically normal adults. A secondary goal was to examine whether vascular risk influences gray matter atrophy independently from markers of white matter injury.
Methods
Participants were 196 adults (age 73.8 ± 6.1 years) from the Harvard Aging Brain Study. Baseline Aβ burden was quantified with Pittsburgh compound B PET. Baseline vascular risk was measured with the Framingham Heart Study cardiovascular disease risk score. Brain atrophy was quantified longitudinally with structural MRI over a median of 4.50 (±1.26) years. Cognition was assessed yearly with the …
学术搜索中的文章
JS Rabin, J Pruzin, M Scott, HS Yang, O Hampton… - Neurology, 2022