作者
Chao Dong, Tao Liu, Wei Wen, Nicole A Kochan, Jiyang Jiang, Qiongge Li, Hao Liu, Haijun Niu, Wei Zhang, Yilong Wang, Henry Brodaty, Perminder S Sachdev
发表日期
2018/1/1
期刊
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
卷号
10
页码范围
688-697
出版商
No longer published by Elsevier
简介
Introduction
Informant-reported subjective cognitive decline (iSCD) has been associated with a higher risk of conversion to dementia, but the findings of whole brain functional connectivity strength (FCS) changes in iSCD are limited.
Methods
The sample comprised 39 participants with iSCD and 39 age- and sex- matched healthy controls. The global absolute (aFCS) and relative functional connectivity strengths were estimated using weighted degree centrality and the z-scores of the weighted degree centrality respectively. FreeSurfer was used for measuring cortical thickness.
Results
The aFCS was lower in iSCD primarily in left medial superior frontal, left precuneus, left parietal, right cuneus, and bilateral calcarine; while relative functional connectivity strength was higher in posterior cingulate cortex/precuneus compared with healthy controls. No significant differences in cortical thickness were observed.
Discussion …
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C Dong, T Liu, W Wen, NA Kochan, J Jiang, Q Li, H Liu… - Alzheimer's & Dementia: Diagnosis, Assessment & …, 2018