作者
Sunil K Ahuja, Muthu Saravanan Manoharan, Grace C Lee, Lyle R McKinnon, Justin A Meunier, Maristella Steri, Nathan Harper, Edoardo Fiorillo, Alisha M Smith, Marcos I Restrepo, Anne P Branum, Matthew J Bottomley, Valeria Orrù, Fabio Jimenez, Andrew Carrillo, Lavanya Pandranki, Caitlyn A Winter, Lauryn A Winter, Alvaro A Gaitan, Alvaro G Moreira, Elizabeth A Walter, Guido Silvestri, Christopher L King, Yong-Tang Zheng, Hong-Yi Zheng, Joshua Kimani, T Blake Ball, Francis A Plummer, Keith R Fowke, Paul N Harden, Kathryn J Wood, Martin T Ferris, Jennifer M Lund, Mark T Heise, Nigel Garrett, Kristen R Canady, Salim S Abdool Karim, Susan J Little, Sara Gianella, Davey M Smith, Scott Letendre, Douglas D Richman, Francesco Cucca, Hanh Trinh, Sandra Sanchez-Reilly, Joan M Hecht, Jose A Cadena Zuluaga, Antonio Anzueto, Jacqueline A Pugh, Brian K Agan, Robert Root-Bernstein, Robert A Clark, Jason F Okulicz, Weijing He
发表日期
2023/6/13
期刊
Nature communications
卷号
14
期号
1
页码范围
3286
出版商
Nature Publishing Group UK
简介
Some people remain healthier throughout life than others but the underlying reasons are poorly understood. Here we hypothesize this advantage is attributable in part to optimal immune resilience (IR), defined as the capacity to preserve and/or rapidly restore immune functions that promote disease resistance (immunocompetence) and control inflammation in infectious diseases as well as other causes of inflammatory stress. We gauge IR levels with two distinct peripheral blood metrics that quantify the balance between (i) CD8+ and CD4+ T-cell levels and (ii) gene expression signatures tracking longevity-associated immunocompetence and mortality-associated inflammation. Profiles of IR metrics in ~48,500 individuals collectively indicate that some persons resist degradation of IR both during aging and when challenged with varied inflammatory stressors. With this resistance, preservation of optimal IR tracked (i …
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SK Ahuja, MS Manoharan, GC Lee, LR McKinnon… - Nature communications, 2023