作者
Grace C Lee, Marcos I Restrepo, Nathan Harper, Muthu Saravanan Manoharan, Alisha M Smith, Justin A Meunier, Sandra Sanchez-Reilly, Aamir Ehsan, Anne P Branum, Caitlyn Winter, Lauryn Winter, Fabio Jimenez, Lavanya Pandranki, Andrew Carrillo, Graciela L Perez, Antonio Anzueto, Hanh Trinh, Monica Lee, Joan M Hecht, Celida Martinez-Vargas, Raj T Sehgal, Jose Cadena, Elizabeth A Walter, Kimberly Oakman, Raymond Benavides, Jacqueline A Pugh, Mohamed I Abdalla, Sandra G Adams, Joseph Agnew, Saleem Ali, Jennifer Barker, Angela Birdwell, Stephen Bradford, Heather Briggs, Judith Marin Corral, Jennifer J Dacus, Patrick J Danaher, Scott A DePaul, Jill Dickerson, Jollynn Doanne, Samantha Elbel, Corina Escamilla, Robert Farrar, David Feldman, Julianne Flynn, Delvina Ford, Joanna D Foy, Megan Freeman, Samantha Galley, Maritza Garza, Sherraine Gilman, Jennifer Gomez, Varun K Goyal, Sally Grassmuck, Joshua Hanson, Brande Harris, Gabrielyd Hastings, Audrey Haywood, Cecilia Hinojosa, Tony T Ho, Teri Hopkins, Pamela Jewell, Thomas B Johnson, Vasiliki Kotogiannes, Austin C Lawler, Chadwick S Lester, Stephanie M Levine, Haidee V Lewis, Angel Louder, Charmaine Mainor, Rachel Maldonado, Yvette Martinez, Neil McElligott, Laura Medlin, Myra Mireles, Kathleen Morneau, Samuel B Munro, Anoop Nambiar, Daniel Nassery, Robert Nathanson, Jane O’Rorke, Cheryl Padgett, Sergi Pascual-Guardia, Marisa Patterson, Rogelio Perez, Robert E Phillips, Patrick B Polk, Michael A Pomager, Kristy J Preston, Kevin C Proud, Michelle Rangel, Temple A Ratcliffe, Renee L Reichelderfer, Evan M Renz, Jeanette Ross, Teresa Rudd, Maria E Sanchez, Tammy Sanders, Kevin C Schindler, David Schmit, Claudio Solorzano, Nilam Soni, Win S Tam, Edward J Tovar, Anna R Tyler, Anjuli Vasquez, Maria C Veloso, Steven G Venticinque, Jorge A Villalpando, Melissa Villanueva, Lauren Villegas, Andrew Wallace, Emily Wang, Andreia Williamson, Sadie A Trammell Velasquez, Andrea Yunes, Katharine H Zentner, Scott Letendre, Maristella Steri, Valeria Orrù, Edoardo Fiorillo, Francesco Cucca, Alvaro G Moreira, Nu Zhang, Elizabeth Leadbetter, Brian K Agan, Douglas D Richman, Weijing He, Robert A Clark, Jason F Okulicz, Sunil K Ahuja
发表日期
2021/11/1
期刊
Journal of Allergy and Clinical Immunology
卷号
148
期号
5
页码范围
1176-1191
出版商
Mosby
简介
Background
The risk of severe coronavirus disease 2019 (COVID-19) varies significantly among persons of similar age and is higher in males. Age-independent, sex-biased differences in susceptibility to severe COVID-19 may be ascribable to deficits in a sexually dimorphic protective attribute that we termed immunologic resilience (IR).
Objective
We sought to examine whether deficits in IR that antedate or are induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection independently predict COVID-19 mortality.
Methods
IR levels were quantified with 2 novel metrics: immune health grades (IHG-I [best] to IHG-IV) to gauge CD8+ and CD4+ T-cell count equilibrium, and blood gene expression signatures. IR metrics were examined in a prospective COVID-19 cohort (n = 522); primary outcome was 30-day mortality. Associations of IR metrics with outcomes in non–COVID-19 cohorts (n = 13,461 …
学术搜索中的文章
GC Lee, MI Restrepo, N Harper, MS Manoharan… - Journal of Allergy and Clinical Immunology, 2021