作者
Chen Yu, Sejiro Littleton, Nicholas Giroux, Rose Mathew, Shengli Ding, Joan Kalnitsky, Yuchen Yang, Elizabeth Petzold, Hong Chung, Grecia Rivera, Tomer Rotstein, Rui Xi, Emily Ko, Ephraim Tsalik, Gregory Sempowski, Thomas Denny, Thomas Burke, Micah McClain, Christopher Woods, Xiling Shen, Daniel Saban
发表日期
2021/2/22
期刊
Med
卷号
2
期号
6
页码范围
755-772
简介
Background
Sexual dimorphisms in immune responses contribute to coronavirus disease 2019 (COVID-19) outcomes, but the mechanisms governing this disparity remain incompletely understood.
Methods
We carried out sex-balanced sampling of peripheral blood mononuclear cells from hospitalized and non-hospitalized individuals with confirmed COVID-19, uninfected close contacts, and healthy control individuals for 36-color flow cytometry and single-cell RNA sequencing.
Findings
Our results revealed a pronounced reduction of circulating mucosal-associated invariant T (MAIT) cells in infected females. Integration of published COVID-19 airway tissue datasets suggests that this reduction represented a major wave of MAIT cell extravasation during early infection in females. Moreover, MAIT cells from females possessed an immunologically active gene signature, whereas cells from males were pro-apoptotic …
学术搜索中的文章
C Yu, S Littleton, NS Giroux, R Mathew, S Ding… - Med, 2021