作者
Patricia Grady-Dominguez, Alison Cogan, Allan Kozlowski, Katherine O'Brien, Joseph Giacino, Yelena Bodien, James Graham, Stephen Aichele, Paige Ford, Trisha Kot, Trudy Mallinson, Jennifer Weaver
发表日期
2024/4/1
期刊
Archives of Physical Medicine and Rehabilitation
卷号
105
期号
4
页码范围
e126
出版商
WB Saunders
简介
Research Objectives
To establish indices of responsiveness on the Coma Recovery Scale - Revised (CRS-R) for patients with disorders of consciousness (DoC): (1) minimal detectable change with 95% confidence interval (MDC95), (2) conditional MDC95 (cMDC), and (3) distribution-based minimally clinically important difference (MCID). To compare participants’ change in CRS-R scores between the control and placebo group of the Amantadine Trial.
Design
Retrospective analysis of data collected during a randomized, placebo-controlled clinical trial of participants with DoC.
Setting
Inpatient rehabilitation facilities.
Participants
180 adult participants with DoC resulting from traumatic brain injury (age: mean=36.4 years, SD=15.3; gender: 130 males, 50 females ; condition: 92 Amantadine, 88 placebo).
Interventions
Amantadine or placebo was administered to patients for four weeks.
Main Outcome Measures
CRS-R was …
学术搜索中的文章
P Grady-Dominguez, A Cogan, A Kozlowski, K O'Brien… - Archives of Physical Medicine and Rehabilitation, 2024