作者
Stefan Schwab, Dimitrios Georgiadis, Jörg Berrouschot, Peter D Schellinger, Carmelo Graffagnino, Stephan A Mayer
发表日期
2001/9/1
期刊
Stroke
卷号
32
期号
9
页码范围
2033-2035
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose— Moderate hypothermia decreases ischemic damage in experimental stroke models. This multicenter study was performed to evaluate (1) the safety and feasibility of moderate hypothermia and (2) its potential to reduce intracranial hypertension in acute stroke patients.
Methods— Fifty prospective patients with cerebral infarction involving at least the complete middle cerebral artery territory treated with moderate hypothermia were evaluated. Hypothermia was induced with the use of cooling blankets as well as alcohol and ice bags within 22±9 hours after stroke onset and maintained for 24 to 72 hours; subsequently, patients passively rewarmed over a mean duration of 17 hours. Outcome was assessed at 4 weeks and at 3 months.
Results— Time required for cooling to <33°C varied from 3.5 to 11 hours. The most frequent complications of hypothermic therapy were …
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