作者
Cecilia Gotti, Francesco Clementi, Alice Fornari, Annalisa Gaimarri, Stefania Guiducci, Irene Manfredi, Milena Moretti, Patrizia Pedrazzi, Luca Pucci, Michele Zoli
发表日期
2009/10/1
来源
Biochemical pharmacology
卷号
78
期号
7
页码范围
703-711
出版商
Elsevier
简介
Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels present in the central and peripheral nervous systems, that are permeable to mono- and divalent cations. They share a common basic structure but their pharmacological and functional properties arise from the wide range of different subunit combinations making up distinctive subtypes. nAChRs are involved in many physiological functions in the central and peripheral nervous systems, and are the targets of the widely used drug of abuse nicotine. In addition to tobacco dependence, changes in their number and/or function are associated with neuropsychiatric disorders, ranging from epilepsy to dementia. Although some of the neural circuits involved in the acute and chronic effects of nicotine have been identified, much less is known about which native nAChR subtypes are involved in specific physiological functions and …
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