作者
Phil D Livingstone, Jayaraman Srinivasan, James NC Kew, Lee A Dawson, Cecilia Gotti, Milena Moretti, Mohammed Shoaib, Susan Wonnacott
发表日期
2009/2
期刊
European Journal of Neuroscience
卷号
29
期号
3
页码范围
539-550
出版商
Blackwell Publishing Ltd
简介
Nicotine enhances attentional and working memory aspects of executive function in the prefrontal cortex (PFC) where dopamine plays a major role. Here, we have determined the nicotinic acetylcholine receptor (nAChR) subtypes that can modulate dopamine release in rat PFC using subtype‐selective drugs. Nicotine and 5‐Iodo‐A‐85380 (β2* selective) elicited [3H]dopamine release from both PFC and striatal prisms in vitro and dopamine overflow from medial PFC in vivo. Blockade by dihydro‐β‐erythroidine supports the participation of β2* nAChRs. However, insensitivity of nicotine‐evoked [3H]dopamine release to α‐conotoxin‐MII in PFC prisms suggests no involvement of α6β2* nAChRs, in contrast to the striatum, and this distinction is supported by immunoprecipitation of nAChR subunits from these tissues. The α7 nAChR‐selective agonists choline and Compound A also promoted dopamine release from …
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PD Livingstone, J Srinivasan, JNC Kew, LA Dawson… - European Journal of Neuroscience, 2009