作者
Elaine Perry, Carmen Martin-Ruiz, Mandy Lee, Martin Griffiths, Mary Johnson, Margaret Piggott, Vahram Haroutunian, Joseph Daniel Buxbaum, Janne Nãsland, Kenneth Davis, Cecilia Gotti, Francesco Clementi, Socrates Tzartos, Onsat Cohen, Hermona Soreq, Evelyn Jaros, Robert Perry, Clive Ballard, Ian McKeith, Jennifer Court
发表日期
2000/3/30
期刊
European journal of pharmacology
卷号
393
期号
1-3
页码范围
215-222
出版商
Elsevier
简介
Human brain ageing is associated with reductions in a variety of nicotinic receptors subtypes, whereas changes in age-related disorders including Alzheimer's disease or Parkinson's disease are more selective. In Alzheimer's disease, in the cortex there is a selective loss of the α4 (but not α3 or 7) subunit immunoreactivity and of nicotine or epibatidine binding but not α-bungarotoxin binding. Epibatidine binding is inversely correlated with clinical dementia ratings and with the level of Aβ1–42, but not related to plaque or tangle densities. In contrast, α-bungarotoxin binding is positively correlated with plaque densities in the entorhinal cortex. In human temporal cortex loss of acetylcholinesterase catalytic activity is positively correlated with decreased epibatidine binding and in a transgenic mouse model over expressing acetylcholinesterase, epibatidine binding is elevated. In Parkinson's disease, loss of striatal nicotine …
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E Perry, C Martin-Ruiz, M Lee, M Griffiths, M Johnson… - European journal of pharmacology, 2000