作者
Carmen Saenz, Qing Fang, Thiyagarajan Gnanasekaran, Samuel Addison Jack Trammell, Jesse Arnold Buijink, Paola Pisano, Michael Wierer, Frédéric Moens, Bettina Lengger, Asker Brejnrod, Manimozhiyan Arumugam
发表日期
2023/10/17
期刊
Microbiology Spectrum
卷号
11
期号
5
页码范围
e03933-22
出版商
American Society for Microbiology
简介
Clostridioides difficile infection (CDI) is a major health concern and one of the leading causes of hospital-acquired diarrhea in many countries. C. difficile infection is challenging to treat as C. difficile is resistant to multiple antibiotics. Alternative solutions are needed as conventional treatment with broad-spectrum antibiotics often leads to recurrent CDI. Recent studies have shown that specific microbiota-based therapeutics such as bile acids (BAs) are promising approaches to treat CDI. Clostridium scindens encodes the bile acid-induced (bai) operon that carries out 7-alpha-dehydroxylation of liver-derived primary BAs to secondary BAs. This biotransformation is thought to increase the antibacterial effects of BAs on C. difficile. Here, we used an automated multistage fermentor to study the antibacterial actions of C. scindens and BAs on C. difficile in the presence/absence of a gut microbial community derived from …
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C Saenz, Q Fang, T Gnanasekaran, SAJ Trammell… - Microbiology Spectrum, 2023