作者
Trisha J Grevengoed, Samuel AJ Trammell, Jens S Svenningsen, Mikhail V Makarov, Thomas Svava Nielsen, Jens Christian Brings Jacobsen, Jonas T Treebak, Philip C Calder, Marie E Migaud, Benjamin F Cravatt, Matthew P Gillum
发表日期
2021/3/18
期刊
The Journal of Clinical Investigation
卷号
131
期号
6
出版商
American Society for Clinical Investigation
简介
Omega-3 fatty acids from fish oil reduce triglyceride levels in mammals, yet the mechanisms underlying this effect have not been fully clarified, despite the clinical use of omega-3 ethyl esters to treat severe hypertriglyceridemia and reduce cardiovascular disease risk in humans. Here, we identified in bile a class of hypotriglyceridemic omega-3 fatty acid–derived N-acyl taurines (NATs) that, after dietary omega-3 fatty acid supplementation, increased to concentrations similar to those of steroidal bile acids. The biliary docosahexaenoic acid–containing (DHA-containing) NAT C22:6 NAT was increased in human and mouse plasma after dietary omega-3 fatty acid supplementation and potently inhibited intestinal triacylglycerol hydrolysis and lipid absorption. Supporting this observation, genetic elevation of endogenous NAT levels in mice impaired lipid absorption, whereas selective augmentation of C22:6 NAT levels …
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TJ Grevengoed, SAJ Trammell, JS Svenningsen… - The Journal of Clinical Investigation, 2021