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Objective

Augmenting NAD+ metabolism through dietary provision of NAD+ precursor vitamins translate to improved glucose handling in rodent models of obesity and diabetes. Preclinical evidence suggests that the NAD+/SIRT1 axis may be implicated in modulating important gut-related aspects of glucose regulation. We aimed to test if NAD+ precursor supplementation with nicotinamide riboside (NR) affects β-cell function, α-cell function, and incretin hormone secretion as well as circulating bile acids levels in humans.

Design

A 12-week randomized, double-blind, placebo-controlled, and parallel-group trial in 40 obese, insulin-resistant males allocated to NR 1,000 mg twice daily (n= 20) or placebo (n= 20).

Methods

2-hour 75 gram oral glucose tolerance tests (OGTT) were performed before and after the intervention and plasma concentrations of glucose, insulin, C-peptide, glucagon, GLP-1, and GIP were …