作者
Luciana L Molinero, Mercedes B Fuertes, María Victoria Girart, Leonardo Fainboim, Gabriel A Rabinovich, Mónica A Costas, Norberto W Zwirner
发表日期
2004/11/1
期刊
The Journal of Immunology
卷号
173
期号
9
页码范围
5583-5590
出版商
American Association of Immunologists
简介
MHC class I-related chain A gene (MICA) is a stress-regulated, HLA-related molecule which exhibits a restricted pattern of expression. MICA protein is up-regulated on different tumor cells, and is recognized by the lectin-like NKG2D molecule expressed by cytotoxic γδ T lymphocytes, CD8+ αβ T lymphocytes, and NK cells. Although MICA is not expressed on resting lymphocytes, we demonstrated that it is induced on activated T cells. Because NF-κB is actively involved in T cell activation, and is constitutively activated in many tumors, here we investigated whether NF-κB may modulate MICA expression. Treatment with the NF-κB inhibitor sulfasalazine (Sz) resulted in a dose-dependent inhibition of MICA expression in anti-CD3-and anti-CD28/PMA-activated T lymphocytes, as assessed by Western blot and RT-PCR analysis. Moreover, Sz also down-regulated MICA expression on epithelial tumor HeLa cells. MICA …
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LL Molinero, MB Fuertes, MV Girart, L Fainboim… - The Journal of Immunology, 2004