作者
David W Kimberlin, Chin-Yu Lin, Richard F Jacobs, Dwight A Powell, Lisa M Frenkel, William C Gruber, Mobeen Rathore, John S Bradley, Pamela S Diaz, Mary Kumar, Ann M Arvin, Kathleen Gutierrez, Mark Shelton, Leonard B Weiner, John W Sleasman, Teresa Murguı́a de Sierra, Seng-Jaw Soong, Jan Kiell, Fred D Lakeman, Richard J Whitley, National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Groupa
发表日期
2001/8/1
期刊
Pediatrics
卷号
108
期号
2
页码范围
223-229
出版商
American Academy of Pediatrics
简介
Objective
During the 2 decades in which effective antiviral therapies have been available for neonatal herpes simplex virus (HSV) disease, changes have been documented not only in the outcomes of infected infants, but also in the natural history of the disease itself. Numerous studies previously have reported that early institution of antiviral therapy is beneficial to the outcome of the disease. The objective of this study was to provide an update of neonatal HSV disease to identify means by which future improvements in the management of HSV-infected neonates can be made.
Design/Methods
Neonates enrolled in 2 studies of parenteral acyclovir for the treatment of neonatal HSV disease provided the data source. The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group conducted the studies between 1981 and 1997. A total of 186 patients are …
引用总数
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