作者
Ljiljana V Vasovic, James Littlejohn, Dalia Alqunaibit, Alicia Dillard, Yuqing Qiu, Sophie Rand, Matthew Bronstein, Cameron J Gibson, Anton G Kelly, Christina Lee, Jennifer A Minneman, Mayur Narayan, Jian Shou, Kira E Smith, Cassandra V Villegas, Robert J Winchell, Melissa M Cushing, Philip S Barie
发表日期
2022/4/1
期刊
Surgery
卷号
171
期号
4
页码范围
1092-1099
出版商
Mosby
简介
Objectives
We evaluated rotational thromboelastometry tracings in 44 critically ill coronavirus disease 2019 patients, to determine whether there is a viscoelastic fingerprint and to test the hypothesis that the diagnosis and prediction of venous thromboembolism would be enhanced by the addition of rotational thromboelastometry testing.
Results
Rotational thromboelastometry values reflected an increase in clot strength for the EXTEM, INTEM, and FIBTEM assays beyond the reference range. No hyperfibrinolysis was noted. Fibrinolysis shutdown was present but did not correlate with thrombosis; 32% (14/44) of patients experienced a thrombotic episode. For every 1 mm increase of FIBTEM maximum clot formation, the odds of developing thrombosis increased 20% (95% confidence interval, 0–40%, P = .043), whereas for every 1,000 ng/mL increase in D-dimer, the odds of thrombosis increased by 70% (95 …
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LV Vasovic, J Littlejohn, D Alqunaibit, A Dillard, Y Qiu… - Surgery, 2022