作者
Jaffar M Khan, Toby Rogers, William H Schenke, Adam B Greenbaum, Vasilis C Babaliaros, Gaetano Paone, Rajiv Ramasawmy, Marcus Y Chen, Daniel A Herzka, Robert J Lederman
发表日期
2018/9/1
期刊
Catheterization and Cardiovascular Interventions
卷号
92
期号
3
页码范围
E175-E184
简介
Objectives
Pledget‐assisted suture tricuspid valve annuloplasty (PASTA) is a novel technique using marketed equipment to deliver percutaneous trans‐annular sutures to create a double‐orifice tricuspid valve.
Background
Tricuspid regurgitation is a malignant disease with high surgical mortality and no commercially available transcatheter solution in the US.
Methods
Two iterations of PASTA were tested using trans‐apical or trans‐jugular access in swine. Catheters directed paired coronary guidewires to septal and lateral targets on the tricuspid annulus under fluoroscopic and echocardiographic guidance. Guidewires were electrified to traverse the annular targets and exchanged for pledgeted sutures. The sutures were drawn together and knotted, apposing septal and lateral targets, creating a double orifice tricuspid valve.
Results
Twenty‐two pigs underwent PASTA. Annular and chamber dimensions were …
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