作者
Yosuke Ishii, Thoralf Thamm, Jia Guo, Mohammad Mehdi Khalighi, Mirwais Wardak, Dawn Holley, Harsh Gandhi, Jun Hyung Park, Bin Shen, Gary K Steinberg, Frederick T Chin, Greg Zaharchuk, Audrey Peiwen Fan
发表日期
2020/1
期刊
Journal of Magnetic Resonance Imaging
卷号
51
期号
1
页码范围
183-194
出版商
John Wiley & Sons, Inc.
简介
Background
H215O‐positron emission tomography (PET) is considered the reference standard for absolute cerebral blood flow (CBF). However, this technique requires an arterial input function measured through continuous sampling of arterial blood, which is invasive and has limitations with tracer delay and dispersion.
Purpose
To demonstrate a new noninvasive method to quantify absolute CBF with a PET/MRI hybrid scanner. This blood‐free approach, called PC‐PET, takes the spatial CBF distribution from a static H215O‐PET scan, and scales it to the whole‐brain average CBF value measured by simultaneous phase‐contrast MRI.
Study Type
Observational.
Subjects
Twelve healthy controls (HC) and 13 patients with Moyamoya disease (MM) as a model of chronic ischemic disease.
Field Strength/Sequences
3T/2D cardiac‐gated phase‐contrast MRI and H215O‐PET.
Assessment
PC‐PET CBF values …
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Y Ishii, T Thamm, J Guo, MM Khalighi, M Wardak… - Journal of Magnetic Resonance Imaging, 2020