作者
Audrey P Fan, Mohammad M Khalighi, Jia Guo, Yosuke Ishii, Jarrett Rosenberg, Mirwais Wardak, Jun Hyung Park, Bin Shen, Dawn Holley, Harsh Gandhi, Tom Haywood, Prachi Singh, Gary K Steinberg, Frederick T Chin, Greg Zaharchuk
发表日期
2019/2
期刊
Stroke
卷号
50
期号
2
页码范围
373-380
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose
Noninvasive imaging of brain perfusion has the potential to elucidate pathophysiological mechanisms underlying Moyamoya disease and enable clinical imaging of cerebral blood flow (CBF) to select revascularization therapies for patients. We used hybrid positron emission tomography (PET)/magnetic resonance imaging (MRI) technology to characterize the distribution of hypoperfusion in Moyamoya disease and its relationship to vessel stenosis severity, through comparisons with a normative perfusion database of healthy controls.
Methods
To image CBF, we acquired [15O]-water PET as a reference and simultaneously acquired arterial spin labeling (ASL) MRI scans in 20 Moyamoya patients and 15 age-matched, healthy controls on a PET/MRI scanner. The ASL MRI scans included a standard single-delay ASL scan with postlabel delay of 2.0 s and a multidelay scan with 5 postlabel …
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AP Fan, MM Khalighi, J Guo, Y Ishii, J Rosenberg… - Stroke, 2019