作者
Ryusuke Nakamoto, Valentina Ferri, Heying Duan, Negin Hatami, Mahima Goel, Jarrett Rosenberg, Richard Kimura, Mirwais Wardak, Tom Haywood, Rowaid Kellow, Bin Shen, Walter Park, Andrei Iagaru, Sanjiv Sam Gambhir
发表日期
2021/11/3
期刊
European Journal of Nuclear Medicine and Molecular Imaging
页码范围
1-10
出版商
Springer Berlin Heidelberg
简介
Purpose
A novel cystine-knot peptide–based PET radiopharmaceutical, 18F-FP-R01-MG-F2 (knottin), was developed to selectively bind to human integrin αvβ6 which is overexpressed in pancreatic cancer. The purpose of this study is to evaluate the safety, biodistribution, dosimetry, and lesion uptake of 18F-FP-R01-MG-F2 in patients with pancreatic cancer.
Methods
Fifteen patients (6 men, 9 women) with histologically confirmed pancreatic cancer were prospectively enrolled and underwent knottin PET/CT between March 2017 and February 2021 (ClinicalTrials.gov Identifier NCT02683824). Vital signs and laboratory results were collected before and after the imaging scans. Maximum standardized uptake values (SUVmax) and mean SUV (SUVmean) were measured in 24 normal tissues and pancreatic cancer lesions for each patient. From the biodistribution …
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R Nakamoto, V Ferri, H Duan, N Hatami, M Goel… - European Journal of Nuclear Medicine and Molecular …, 2022