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A study of the pharmacokinetic profile (oral absorption and renal excretion) of inositol hexaphosphate or phytate (IP₆) is presented. Seven healthy volunteers were following a IP₆ poor diet (IP₆PD) in a first period, and on IP₆ normal diet (IP₆ND) in a second one. When following the IP₆PD they become deficient in IP₆, the basal levels found in plasma (0.07± 0.01 mg/L) being clearly lower than those found when IP₆ND was consumed (0.26± 0.03 mg/L). During the restriction period the maximum concentration in plasma were obtained 4 h after the ingestion of a single dose of IP₆, observing almost the same renal excretion profiles for the three different comercial sources and doses. After the IP₆ restriction period, volunteers were on IP₆ND, reaching normal plasma and urinary IP₆ values in 16 days. Thus, the normal plasma and urinary concentrations, can be obtained either by comsumption of a IP₆ND taking a long …