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Due to the increasing interest of InsP₆ on human health, the aim of this paper is to compare the levels of highly phosphorilated inositols (InsP₄, InsP₅ and InsP₆) in organs and biological fluids of rats and to study the influence of the presence and absence of InsP₆ in diets. Thus, for this purpose, the variation of InsP₄, InsP₅ and InsP₆ levels in organs and biological fluids of rats submitted to two different diets were studied. In the AIN-76A diet no InsP₆ was present, yet the other was a 1% InsP₆ modified diet (AIN-76A + 1% InsP₆). The highest InsP₄, InsP₅ and InsP₆ levels were found to be 10-fold superior in the brain than those found in the kidney. When the InsP₆ was eliminated from the diet, the InsP₆ levels decreased dramatically (97.2% in kidney, 89.8% in brain, 100% in bone, 90.5% in plasma and 98.1% in urine), the InsP₅ levels showed an important decrease (61.2% in kidney, 45.5% in brain, 28.1% in bone …