作者
J Clark, G Attard, S Jhavar, P Flohr, A Reid, J De-Bono, R Eeles, P Scardino, J Cuzick, G Fisher, MD Parker, CS Foster, D Berney, G Kovacs, CS Cooper
发表日期
2008/3
期刊
Oncogene
卷号
27
期号
14
页码范围
1993-2003
出版商
Nature Publishing Group
简介
An ERG gene ‘break-apart’fluorescence in situ hybridization (FISH) assay has been used to screen whole-mount prostatectomy specimens for rearrangements at the ERG locus. In cancers containing ERG alterations the observed pattern of changes was often complex. Different categories of ERG gene alteration were found either together in a single cancerous region or within separate foci of cancer in the same prostate slice. In some cases the juxtaposition of particular patterns of ERG alterations suggested possible mechanisms of tumour progression. Prostates harbouring ERG alterations commonly also contained cancer that lacked rearrangements of the ERG gene. A single trans-urethral resection of the prostate specimen examined harboured both ERG and ETV1 gene rearrangements demonstrating that the observed complexity may, at least in part, be explained by multiple ETS gene alterations arising …
引用总数
学术搜索中的文章
J Clark, G Attard, S Jhavar, P Flohr, A Reid, J De-Bono… - Oncogene, 2008