作者
J Clark, S Merson, S Jhavar, P Flohr, S Edwards, CS Foster, R Eeles, FL Martin, DH Phillips, M Crundwell, T Christmas, A Thompson, C Fisher, G Kovacs, CS Cooper
发表日期
2007/4
期刊
Oncogene
卷号
26
期号
18
页码范围
2667-2673
出版商
Nature Publishing Group
简介
TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human prostates. Fourteen distinct hybrid transcripts are characterized, each containing different combinations of sequences from the TMPRSS2 and ERG genes. The transcripts include two that are predicted to encode a normal full-length ERG protein, six that encode N-terminal truncated ERG proteins and one that encodes a TMPRSS2-ERG fusion protein. Interestingly, distinct patterns of hybrid transcripts were found in samples taken from separate regions of individual cancer-containing prostates, suggesting that TMPRSS2-ERG gene fusions may be arising independently in different regions of a single prostate.
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J Clark, S Merson, S Jhavar, P Flohr, S Edwards… - Oncogene, 2007