作者
Sameer Jhavar, Daniel Brewer, Sandra Edwards, Zsofia Kote‐Jarai, Gerhardt Attard, Jeremy Clark, Penny Flohr, Timothy Christmas, Alan Thompson, Matthew Parker, Christopher Shepherd, Ulf‐Hakan Stenman, Tania Marchbank, Raymond J Playford, Christopher Woodhouse, Christopher Ogden, Cyril Fisher, Gyula Kovacs, Cathy Corbishley, Charles Jameson, Andy Norman, Johann De‐Bono, Anders Bjartell, Rosalind Eeles, Colin S Cooper
发表日期
2009/5
期刊
BJU international
卷号
103
期号
9
页码范围
1256-1269
出版商
Blackwell Publishing Ltd
简介
OBJECTIVE
To integrate the mapping of ERG alterations with the collection of expression microarray (EMA) data, as previous EMA analyses have failed to consider the genetic heterogeneity and complex patterns of ERG alteration frequently found in cancerous prostates.
MATERIALS AND METHODS
We determined genome‐wide expression levels with GeneChip Human Exon 1.0 ST arrays (Affymetrix, Santa Clara, CA, USA) using RNA prepared from 35 specimens of prostate cancer from 28 prostates.
RESULTS
The expression profiles showed clustering, in unsupervised hierarchical analyses, into two distinct prostate cancer categories, with one group strongly associated with indicators of poor clinical outcome. The two categories are not tightly linked to ERG status. By analysis of the data we identified a subgroup of cancers lacking ERG rearrangements that showed an outlier pattern of SPINK1 mRNA …
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S Jhavar, D Brewer, S Edwards, Z Kote‐Jarai, G Attard… - BJU international, 2009