作者
Daniel B Horton, Frank I Scott, Kevin Haynes, Mary E Putt, Carlos D Rose, James D Lewis, Brian L Strom
发表日期
2015/8/1
期刊
Pediatrics
卷号
136
期号
2
页码范围
e333-e343
出版商
American Academy of Pediatrics
简介
BACKGROUND AND OBJECTIVE
Recent evidence has linked childhood antibiotic use and microbiome disturbance to autoimmune conditions. This study tested the hypothesis that antibiotic exposure was associated with newly diagnosed juvenile idiopathic arthritis (JIA).
METHODS
We performed a nested case–control study in a population-representative medical records database from the United Kingdom. Children with newly diagnosed JIA were compared with age- and gender-matched control subjects randomly selected from general practices containing at least 1 case, excluding those with inflammatory bowel disease, immunodeficiency, or other systemic rheumatic diseases. Conditional logistic regression was used to examine the association between antibacterial antibiotics (including number of antibiotic courses and timing) and JIA after adjusting for significant confounders …
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DB Horton, FI Scott, K Haynes, ME Putt, CD Rose… - Pediatrics, 2015