作者
Daniel B Horton, Kevin Haynes, Michelle R Denburg, Mihir M Thacker, Carlos D Rose, Mary E Putt, Mary B Leonard, Brian L Strom
发表日期
2017/7/1
期刊
BMJ open
卷号
7
期号
7
页码范围
e016788
出版商
British Medical Journal Publishing Group
简介
Objectives
We studied oral glucocorticoids and osteonecrosis, a rare but serious bone disease, in individuals with various chronic inflammatory diseases. We hypothesised that we would find stronger associations in adults versus children and in people with autoimmune diseases.
Design
Retrospective cohort study.
Setting
Population-representative data (1994–2013) from general practices in the UK.
Participants
Children and adults diagnosed with asthma; inflammatory bowel disease; juvenile, psoriatic or rheumatoid arthritis; psoriasis; or systemic lupus.
Exposures
Oral glucocorticoid patterns.
Primary and secondary outcome measures
Diagnosed osteonecrosis (primary) and osteonecrosis plus clinical features (eg, symptoms, pain medication, surgical repair) (secondary). Discrete time failure models estimated the adjusted hazard ratio (aHR) of incident osteonecrosis following oral glucocorticoid exposure. Hypothesis …
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DB Horton, K Haynes, MR Denburg, MM Thacker… - BMJ open, 2017