作者
Mohammed Ali Azam, Praloy Chakraborty, Mahmoud M Bokhari, Keith Dadson, Beibei Du, Stéphane Massé, Daoyuan Si, Ahmed Niri, Arjun K Aggarwal, Patrick FH Lai, Sheila Riazi, Filio Billia, Kumaraswamy Nanthakumar
发表日期
2021/12/1
期刊
Heart Rhythm O2
卷号
2
期号
6
页码范围
733-741
出版商
Elsevier
简介
Background
Doxorubicin (Dox) is a potent chemotherapeutic agent, but its usage is limited by dose-dependent cardiotoxicity. Intracellular calcium dysregulation has been reported to be involved in doxorubicin-induced cardiomyopathy (DICM). The cardioprotective role of RyR stabilizer dantrolene (Dan) on the calcium dynamics of DICM has not yet been explored.
Objective
To evaluate the effects of dantrolene on intracellular calcium dysregulation and cardiac contractile function in a DICM model.
Methods
Adult male C57BL/6 mice were randomized into 4 groups: (1) Control, (2) Dox Only, (3) Dan Only, and (4) Dan + Dox. Fractional shortening (FS) and left ventricular ejection fraction (LVEF) were assessed by echocardiography. In addition, mice were sacrificed 2 weeks after doxorubicin injection for optical mapping of the heart in a Langendorff setup.
Results
Treatment with Dox was associated with a reduction in both …
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MA Azam, P Chakraborty, MM Bokhari, K Dadson, B Du… - Heart Rhythm O2, 2021