作者
Ishu Arpan, Rebecca J Willcocks, Sean C Forbes, Richard S Finkel, Donovan J Lott, William D Rooney, William T Triplett, Claudia R Senesac, Michael J Daniels, Barry J Byrne, Erika L Finanger, Barry S Russman, Dah-Jyuu Wang, Gihan I Tennekoon, Glenn A Walter, HL Sweeney, Krista Vandenborne
发表日期
2014/9/9
期刊
Neurology
卷号
83
期号
11
页码范围
974-980
出版商
Lippincott Williams & Wilkins
简介
Objective
To evaluate the effects of corticosteroids on the lower extremity muscles in boys with Duchenne muscular dystrophy (DMD) using MRI and magnetic resonance spectroscopy (MRS).
Methods
Transverse relaxation time (T2) and fat fraction were measured by MRI/MRS in lower extremity muscles of 15 boys with DMD (age 5.0–6.9 years) taking corticosteroids and 15 corticosteroid-naive boys. Subsequently, fat fraction was measured in a subset of these boys at 1 year. Finally, MRI/MRS data were collected from 16 corticosteroid-naive boys with DMD (age 5–8.9 years) at baseline, 3 months, and 6 months. Five boys were treated with corticosteroids after baseline and the remaining 11 served as corticosteroid-naive controls.
Results
Cross-sectional comparisons demonstrated lower muscle T2 and less intramuscular (IM) fat deposition in boys with DMD on corticosteroids, suggesting reduced inflammation/damage …
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I Arpan, RJ Willcocks, SC Forbes, RS Finkel, DJ Lott… - Neurology, 2014