作者
Claudia R Senesac, Donovan J Lott, Sean C Forbes, Sunita Mathur, Ishu Arpan, Emily S Senesac, Glenn A Walter, Krista Vandenborne
发表日期
2015/7/1
期刊
Physical therapy
卷号
95
期号
7
页码范围
978-988
出版商
Oxford University Press
简介
Background
Duchenne muscular dystrophy (DMD), an inherited recessive X chromosome-linked disease, is the most severe childhood form of muscular dystrophy. Boys with DMD experience muscle loss, with infiltration of intramuscular fat into muscles.
Objectives
This case series describes the progression of DMD in boys using magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Magnetic resonance results are then compared with an established functional timed test.
Methods
Four boys with DMD and 4 healthy age-matched controls were chosen from a larger cohort. Boys with DMD were assessed at 4 time points over 2 years, with controls assessed at baseline only. Progression of the disease was documented by assessing the plantar flexors using MRI and MRS techniques and by assessing ambulation using the 30-Foot Fast …
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CR Senesac, DJ Lott, SC Forbes, S Mathur, I Arpan… - Physical therapy, 2015