作者
Abhinandan Batra, Ann Harrington, Donovan J Lott, Rebecca Willcocks, Claudia R Senesac, William McGehee, Dandan Xu, Sunita Mathur, Michael J Daniels, William D Rooney, Sean C Forbes, William Triplett, Jasjit K Deol, Ishu Arpan, Roxanne Bendixen, Richard Finkel, Erika Finanger, Gihan Tennekoon, Barry Byrne, Barry Russman, H Lee Sweeney, Glenn Walter, Krista Vandenborne
发表日期
2018/10/1
期刊
American journal of physical medicine & rehabilitation
卷号
97
期号
10
页码范围
734-740
出版商
LWW
简介
Objective
The main objective of this study was to examine the effect of disease on strength in two functionally important lower limb muscles for a period of 2 yrs in children with Duchene muscular dystrophy.
Design
Seventy-seven Duchene muscular dystrophy children participated in this study. Plantar flexors, knee extensors, strength, and performance on timed tests (6-min walk, 4-stairs, 10-m walk, supine-up) were assessed yearly for 2 yrs. Multivariate normal regression was used to assess changes in strength over time in the Duchene muscular dystrophy group. Spearman correlations were computed to examine relationship between strength and function.
Results
Normalized plantar flexor and knee extensor strength showed a significant decrease (P< 0.05) over 2 yrs, with larger declines in knee extensor. At baseline, knee extensor strongly correlated with performance on timed tests. However, plantar flexor strength …
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A Batra, A Harrington, DJ Lott, R Willcocks… - American journal of physical medicine & rehabilitation, 2018