作者
Jaclyn M Eissman, Derek B Archer, Shubhabrata Mukherjee, Michael L Lee, Seo‐Eun Choi, Phoebe Scollard, Emily H Trittschuh, Jesse B Mez, William S Bush, Brian W Kunkle, Adam C Naj, Katherine A Gifford, Alzheimer's Disease Neuroimaging Initiative (ADNI)| Alzheimer's Disease Genetics Consortium (ADGC)| The Alzheimer's Disease Sequencing Project (ADSP), Michael L Cuccaro, Carlos Cruchaga, Margaret A Pericak‐Vance, Lindsay A Farrer, Li‐San Wang, Gerard D Schellenberg, Richard P Mayeux, Jonathan L Haines, Angela L Jefferson, Walter A Kukull, C Dirk Keene, Andrew J Saykin, Paul M Thompson, Eden R Martin, David A Bennett, Lisa L Barnes, Julie A Schneider, Paul K Crane, Timothy J Hohman, Logan Dumitrescu
发表日期
2024/2
期刊
Alzheimer's & Dementia
卷号
20
期号
2
页码范围
1250-1267
简介
BACKGROUND
Women demonstrate a memory advantage when cognitively healthy yet lose this advantage to men in Alzheimer's disease. However, the genetic underpinnings of this sex difference in memory performance remain unclear.
METHODS
We conducted the largest sex‐aware genetic study on late‐life memory to date (Nmales = 11,942; Nfemales = 15,641). Leveraging harmonized memory composite scores from four cohorts of cognitive aging and AD, we performed sex‐stratified and sex‐interaction genome‐wide association studies in 24,216 non‐Hispanic White and 3367 non‐Hispanic Black participants.
RESULTS
We identified three sex‐specific loci (rs67099044—CBLN2, rs719070—SCHIP1/IQCJ‐SCHIP), including an X‐chromosome locus (rs5935633—EGL6/TCEANC/OFD1), that associated with memory. Additionally, we identified heparan sulfate signaling as a sex‐specific pathway and …
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JM Eissman, DB Archer, S Mukherjee, ML Lee… - Alzheimer's & Dementia, 2024