作者
Qiang Liu, Ahmed Hassan, Daniele Pezzati, Basem Soliman, Laura Lomaglio, Patrick Grady, Laurent Del Angel Diaz, Andrea Simioni, Shana Maikhor, John Etterling, Giuseppe D’Amico, Giuseppe Iuppa, Teresa Diago Uso, Koji Hashimoto, Federico Aucejo, Masato Fujiki, Bijan Eghtesad, Kazunari Sasaki, Choon Hyuck David Kwon, Jacek Cywinski, Samuel Irefin, Ana Bennett, William Baldwin, Charles Miller, Cristiano Quintini
发表日期
2020/2
期刊
Liver Transplantation
卷号
26
期号
2
页码范围
215-226
简介
The primary aim of this singlecenter, phase 1 exploratory study was to investigate the safety, feasibility, and impact on intrahepatic hemodynamics of a fresh frozen plasma (FFP)–based perfusate in ex situ liver normothermic machine perfusion (NMP) preservation. Using an institutionally developed perfusion device, 21 livers (13 donations after brain death and 8 donations after circulatory death) were perfused for 3 hours 21 minutes to 7 hours 52 minutes and successfully transplanted. Outcomes were compared in a 1:4 ratio to historical control patients matched according to donor and recipient characteristics and preservation time. Perfused livers presented a very low resistance state with high flow during ex situ perfusion (arterial and portal flows 340 ± 150 and 890 ± 70 mL/minute/kg liver, respectively). This hemodynamic state was maintained even after reperfusion as demonstrated by higher arterial flow …
学术搜索中的文章
Q Liu, A Hassan, D Pezzati, B Soliman, L Lomaglio… - Liver Transplantation, 2020